The present study was conducted to investigate the relationship between the anti-stress and hepato-protective effects of Schisandra\r\nLignans Extract (SLE) on stress-induced liver damage. Seven weeks old male mice were fixed in a restraint tube for 18 h to\r\ninduce liver damage. SLE was orally administered to animals for 5 days at dosages of 100 and 200 mg/kg/day before exposed\r\nto restraint stress. Oral administration of SLE significantly reduced restraint-induced liver damage in experimental animal. SLE\r\nwas further found to significantly alleviate the provocation of corticosterone in stressed mice. SLE also significantly decreased\r\noxidative damage and increased anti-oxidative capability of liver cells by preventing the over production and accumulation of free\r\nradicals. In conclusion, the protective effects of SLE on stress-induced liver damage were confirmed, and the correlation between\r\nhepatoprotective and anti-stress effects of schisandra lignans was possible related to its alleviation on the malignant effects of\r\nstressors for bio-homeostasis, such as balance of oxidation and reduction in cells.
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